Ankascin® 568 is an extract obtained through the controlled fermentation of a type of natural yeast (Monascus purpureus NTU 568). It contains two well-studied active compounds called monascin and ankaflavin, which are primarily responsible for its properties.

Unlike other products derived from so-called “red yeast rice,” Ankascin® 568 contains no monacolin K (a natural substance similar to statins). Therefore, it presents a different profile from that of traditional red yeast rice extracts.

Scientific studies

Various clinical studies in humans have evaluated this ingredient in people with
altered cardiometabolic parameters.

• In a study on people with slightly elevated cholesterol, consumption of
  Ankascin® 568 showed improvements in blood lipid levels compared to placebo
  (https://pmc.ncbi.nlm.nih.gov/articles/PMC9332664/).

• In a study with people with mild to moderate hypertension, Ankascin® 568-P was associated with improvements in cardiovascular health indicators, including lipid profile (https://pubmed.ncbi.nlm.nih.gov/28628970/).

• In a trial with adults with prediabetes, its consumption showed positive effects on sugar control and lipid metabolism (https://pmc.ncbi.nlm.nih.gov/articles/PMC9332536/).

Probiotic strain with a cardiometabolic focus.

Lactobacillus plantarum ECGC 13110402 is a probiotic strain studied for its interaction
with the gut-liver axis, a key system in the regulation of lipid metabolism.

Scientific evidence.

• In a clinical trial in adults with normal to slightly elevated cholesterol, supplementation with Lactobacillus plantarum ECGC 13110402 showed improvements in lipid parameters and blood pressure compared to placebo (https://pubmed.ncbi.nlm.nih.gov/29228000/).
• In a subsequent study in adults with hypercholesterolemia, its daily consumption was associated with significant reductions in total cholesterol, LDL, non-HDL cholesterol, and apolipoprotein B, with no relevant adverse effects (https://doi.org/10.1016/j.jff.2022.104939).
• Scientific evidence suggests that certain probiotic strains may participate in the balance of lipid metabolism through the gut microbiota.

High bioavailability berberine.

Berberine is a plant-derived compound widely researched in the field of
glucolipid metabolism that contributes to the maintenance of normal blood cholesterol levels.

Scientific evidence.
Scientific literature describes a low bioavailability of conventional berberine (https://pubmed.ncbi.nlm.nih.gov/26851175/).

FenuMat™ uses patented technology that:

• Improves the solubility of the compound.
• Promotes its digestive stability.
• Has shown greater bioavailability in pharmacokinetic studies compared to standard
  extracts.